Increased hypoxic stress decreases AMP hydrolysis in rabbit heart
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چکیده
منابع مشابه
Increased cyclic AMP content accelerates protein synthesis in rat heart.
Elevation of cyclic AMP (cAMP) content in perfused rat hearts by exposure to glucagon, forskolin, and 1-methyl-3-isobutylxanthine (IBMX) increased rates of protein synthesis during the second hour of perfusion with buffer that contained glucose in the absence of added insulin. When tetrodotoxin was added to arrest contractile activity, glucagon, forskolin, and IBMX still elevated cAMP content a...
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Chronic hypoxia during gestation and delivery results in oxidative stress and cerebrovascular dysfunction in the neonate. We assessed whether melatonin, a potent antioxidant and potential vasodilator, improves the cerebral vascular function in chronically hypoxic neonatal lambs gestated and born in the highlands (3600 m). Six lambs received melatonin (1 mg/kg per day oral) and six received vehi...
متن کاملSimultaneously Measured Isometric Tension and ATP Hydrolysis in Glycerlnated Fibers from Normal and Hypertrophied Rabbit Heart
Adenosinetriphosphatase (ATPase) activity, isometric tension, and sarcomere length of glycerinated fibers from 14 hypertrophied and 18 normal rabbit hearts were measured simultaneously to characterize the altered performance of hypertrophied myocardium. ATPase activity was assessed radiochromatographically, and contributions from mitochondria, sarcolemma, and sarcoplasmic reticulum were exclude...
متن کاملSimultaneously measured isometric tension and ATP hydrolysis in glycerinated fibers from normal and hypertrophied rabbit heart.
Adenosinetriphosphatase (ATPase) activity, isometric tension, and sarcomere length of glycerinated fibers from 14 hypertrophied and 18 normal rabbit hearts were measured simultaneously to characterize the altered performance of hypertrophied myocardium. ATPase activity was assessed radiochromatographically, and contributions from mitochondria, sarcolemma, and sarcoplasmic reticulum were exclude...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1999
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(99)00207-2